Accurate and extensive regulation of meiotic gene expression is crucial to distinguish germ cells animed blue lotion topical spray from somatic cells.In the fission yeast Schizosaccharomyces pombe, a YTH family RNA-binding protein, Mmi1, directs the nuclear exosome-mediated elimination of meiotic transcripts during vegetative proliferation.Mmi1 als
Abstract Viticulture negatively impacts the environment, biodiversity, and human health; however, despite the widely acknowledged challenges that this intensive agricultural activity poses to sustainable development, measures to reduce its invasiveness are constantly being deferred or rebuffed.Constraints to change are linked to vine cultivation me
Hunchback is a bifunctional transcription factor that can activate and repress gene expression in Drosophila development.We investigated the regulatory DNA sequence features that control Hunchback function by perturbing enhancers for one of its target here genes, even-skipped (eve).While Hunchback directly represses the eve stripe 3+7 enhancer, we
Abstract We consider two BF formulations of the theory here of gravity with a negative cosmological constant, of Plebanski and of MacDowell-Mansouri.Both give the standard Einstein equations in the bulk but differ in expressions of edge charges.We compute the asymptotic charges explicitly in both theories for AdS-Schwarzschild, AdS-Kerr, and AdS-Ta
Background: Triple-negative breast cancer (TNBC) remains difficult to be targeted.SET and cancerous inhibitor of protein phosphatase 2A (CIP2A) are intrinsic protein-interacting inhibitors of protein phosphatase 2A (PP2A) and frequently overexpressed in cancers, whereas reactivating PP2A activity has been postulated as an anti-cancer strategy.Here